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2004 Publications

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.
Chmielnicki E, Benraiss A, Economides AN, Goldman SA
J Neurosci
24(9):2133-42
Age-Related Changes in Vascular Endothelial Growth Factor Dependency and Angiopoietin-1-Induced Plasticity of Adult Blood Vessels
Baffert F, Thurston G, Rochon-Duck M, Le T, Brekken R, McDonald DM
Circ Res
94(7):984-92
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
Daly C, Wong V, Burova E, Wei Y, Zabski S, Griffiths J, Lai KM, Lin HC, Ioffe E, Yancopoulos GD, Rudge JS
Genes Dev
18(9):1060-71
Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice
Bluher S, Moschos S, Bullen J Jr, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleemann MW, Mantzoros CS
Diabetes
53(11):2787-96
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy
Lai KM, Gonzalez M, Poueymirou WT, Kline WO, Na E, Zlotchenko E, Stitt TN, Economides AN, Yancopoulos GD, Glass DJ Mol Cell Biol.
24(21):9295-304
Deletion of ghrelin reveals no effect on food intake, but a primary role in energy balance
Wortley KE, Anderson K, Garcia K, Murray J, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox H, Yancopoulos GD, Wiegand SJ, Sleeman MW
Obes Res.
12(1):170.
Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice
Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT
Am J Pathol.
165(6):1895-906
Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor
Zhou YF, Stabile E, Walker J, Shou M, Baffour R, Yu Z, Rott D, Yancopoulos GD, Rudge JS, Epstein SE
J Am Coll Cardiol.
44(4):897-903
Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature
Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O'Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ
Int J Oncol.
25(3):549-53
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW
PNAS 101(21):8227-32
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD
Proc Natl Acad Sci U S A
101(45):15949-54
IKKbeta/NF-kappaB Activation Causes Severe Muscle Wasting in Mice
Cai D, Frantz JD, Tawa NE Jr, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE
Cell
119(2): 285-298
Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival
Cursiefen C, Cao J, Chen L, Liu Y, Maruyama K, Jackson D, Kruse FE, Wiegand SJ, Dana MR, Streilein JW
Invest Ophthalmol Vis Sci
45(8):2666-73
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM
Am J Pathol.
165(1):35-52